In this study, A total of 60 patients diagnosed with PS  and met the inclusion criteria were enrolled and randomly divided into two groups. The experimental group population, comprised of 30 patients, received a single dose of PRP while the control group population, also comprised of 30 patients, received a single dose of saline injection,  patient reported outcomes were assessed with VAS and ODI scores one week and one month after the injections.

Piriformis syndrome (PS) is the common entrapment neuropathy causing buttock pain. Patients are conventionally treated with lifestyle modification, exercise, non-steroidal anti-inflammatory drugs, corticosteroid or botulinum toxin injections. However, some patients may not respond to these conventional treatment methods. Platelet rich plasma (PRP) injection has been shown to be beneficial in various muscular injuries, but its effects have not yet been investigated in PS.