EXOMINE
19 December 2023 2024-11-22 9:10EXOMINE
YOUTH IS
HIDDEN WITHIN YOUR CELL
Autologous Platelet-Derived
Exosome-Rich
Plasma
Exomine Kit facilitates the release of billions of vesicles by stressing platelets and a minimal amount of other blood cells within PRP. Simultaneously, through its special protocol and devices, it activates platelets, providing a plasma rich in platelet-derived exosomes.
EXOMINE, with its broad applications in aesthetics, orthobiological, and therapeutic interventions, proves to yield effective results in various fields such as skin regeneration, hair loss treatments, spot treatments, joint and connective tissue therapies, and non-healing wounds. This versatile product demonstrates efficacy across diverse domains within the realm of medical aesthetics.
mRNA: Through its support in transferring genetic information to target cells, it plays a critical function in facilitating intercellular communication and the exchange of genetic material.
miRNA: Through the modulation of gene expression, it governs the synthesis of proteins, proving effective in biological processes like cell differentiation, development, and regulation
Protein: Provides intercellular communication and regulatio
Microlyzer Blade Technology
Microlyzer 600µm, with its specially designed blades and structure, induces stress on blood cells, leading to the release of billions of vesicles. It also plays a crucial role in the activation of platelet cells.
Advanced PRX Tube
T-LAB, through collaborative efforts with its highly skilled research and development team collaborating with specialized medical professionals, has developed patented and uniquely designed “Advanced PRX Tube" as a result of studies aimed at enhancing vesicle release of blood cells of specific size and weight. With its special internal design, the product facilitates the release of billions of vesicles, activation of platelet cells, and settling of a very small amount of other blood cells in the pellet.
Safe and Effective
EXOMINE has evolved through years of extensive research and development, driven by T-LAB's expertise and reliability in autologous systems. Offering rapid and effective outcomes, Exomine provides users with an autologous and secure system.
The fact that it is an autologous system obtained from the patient's own blood eliminates the risk of allergic reactions after injection.
As a result of device and protocol studies conducted by T-LAB, EXOMINE achieves an approximate count of 35-40 billion vesicles per mL. With a final product size of approximately 5cc, EXOMINE delivers an industry-leading vesicle count, providing users with an average of 120-150 billion vesicles.
To be defined as exosomes, vesicles need to have sizes ranging from 30-150nm, be analyzed with relevant CD markers, and exhibit high viability. Studies conducted with EXOMINE reveal an average vesicle size of 116nm, with analysis using relevant CD markers confirming that 98% of the vesicles are platelet-derived exosomes. Neutral laboratory results further demonstrate a viability rate of 99%.
NOT EVERY VESICLE IS AN EXOSOME
RESULTS OF NANOSIGHT NS300 NTA
FTLA Concentration 7 Size graph for Experiment: "Striped Tube EV 1-200" (Measurements were conducted at Yeditepe University Biosidal and R&D Laboratories.)
RESULTS OF FLOW CYTOMETRY
CD9 (Platelet) %99,6
CD45 (Pan Leukocyte Marker) %0,3
CD41 (Platelet GPIIb, IIb Integrin) %99,4
CD61 (Platelet glycoprotein GPIIIa) %98,6
CD81 (Target for anti-proliferative antigen 1 [TAPA-1]) %98,5
7 AAD : %98,9
Immunophenotypic measurements were performed using the Beckman Coulter DxFLEX Flow Cytometry system, and the evaluation was completed with the CytExpert DxFLEX software program. (Measurements were implemented at the Private Deren Laboratory)
40,5×109 particles/mL
Average Size: 116.6nm
As a result of the studies carried out, with EXOMINE Kit 40,5×109 According to the results of the conducted studies, it has been demonstrated through impartial laboratory results that 4.5×109 particles/mL of vesicles were obtained using the EXOMINE Kit. The average vesicle size was found to be 116.6 nm. Analysis conducted with relevant CD markers revealed that 98% of the vesicles were exosome-derived, and viability was confirmed to be 99%.
Areas of Application
AESTHETICS
EXOMINE has a broad potential for use in the fields of Aesthetics and Plastic Surgery, Dermatology, and Medical Aesthetics. It is frequently employed in combinations with skin and fat tissue to facilitate soft tissue healing, enhance regional tissue quality, achieve tissue radiance, increase elastin and collagen synthesis to reduce wrinkles, and address hair loss. In dermatology, it is particularly utilized for skin rejuvenation, wrinkle reduction, as well as in the treatment of stretch marks and spot issues. EXOMINE promotes the thickening and volumizing of hair follicles in the affected area, aiding in root growth, making it a common post-hair transplant application for weakened hair.
ORTHOBIOLOGICS
The primary purpose of EXOMINE in the field of Orthopedics and Physical Therapy is to alleviate pain and reduce the need for applications that involve drug injections and surgical interventions, allowing patients to comfortably continue their daily lives. It is commonly used for the healing of tendinosis (chronic tendon injuries at the cellular level), as well as the repair of ligament and connective tissue injuries. Its positive effects are frequently observed in conditions such as fascia-related tissue, known as plantar fasciitis, Achilles tendon injuries, cartilage damage, and bone-related injuries (due to combinations with BMSCs).
THERAPEUTICS
In wound care, EXOMINE yields successful results in situations where surgical options are limited or have a low success rate, such as wounds due to vascular insufficiency, trauma-induced wounds (provided there is no cancer involvement), or diabetic ulcers.
In the field of Ophthalmology, known as the science of the eyes, EXOMINE is particularly used in cases of Corneal Ulcers and Dry Eye syndrome. For instance, in Dry Eye syndrome, EXOMINE is applied using the prepared droplet method instead of the injection method. It is acknowledged that EXOMINE aids in preventing inflammation in cases of Corneal Ulcers.
In Oral and Maxillofacial Surgery, EXOMINE is effective not only in soft tissue but also in stimulating bone and hard tissue. It is clinically utilized in various areas, from gum tissues to jawbone osteonecrosis.
