PRP and Mesotherapy are methods that can be used for skin rejuvenation in two different concepts. In mesotherapies; vitamins, amino acids, minerals, and electrolytes that are needed by the tissues, are given. Since there are many mesotherapy products currently on the market, the mesotherapy product to be applied should be selected by specialist physicians. Moreover, it should be checked whether the product to be used complies with the injection standards. In addition, since mesotherapy products contain many ingredients, people who are prone to allergic reactions should pay attention to whether they are allergic to the products before having a mesotherapy treatment. On the other hand, PRP is based on the isolation of platelets that help the rejuvenation by creating a regenerative effect from the person's own blood and giving them back to their skin. As long as PRP is applied in a sterile way, it does not cause any side effects in the patient and meanwhile the tissues recognize the patient's own blood, no allergic reaction is expected.

These two methods, which have different mechanisms of action, are often compared with each other in terms of their effects. Due to the diversity of mesotherapy products and the relative scarcity of injectable products, there are few studies comparing the two methods. PRP is a well-known method and many publications have been written about it. The necessary conditions to obtain the right PRP have been checked many times, and the effects final PRP results have been studied a lot.

If Mesotherapy and PRP treatments are compared, the activation mechanisms of mesotherapy products and PRP should be examined. Vitamin proteins provided by the mesotherapy method can eliminate the deficiency and provide an outcome on regeneration. However, PRP triggers regeneration by activating cells directly with Growth Factors and offers a more guaranteed treatment. Acting naturally, PRP activates cells to divide, synthesize collagen, and provide the necessary vascularization, thus rejuvenating the skin.

PRP and mesotherapy can be applied to patients as combined treatments. While mesotherapy provides certain stimulating molecules as its mechanism of action, it offers the necessary building blocks that cells may need during regeneration. PRP, on the other hand, sends the "divide" signal to the cells, increasing the awakening of the cells and increasing the synthesis of collagen. There is a high probability of increasing the effects of each other. Combining the two therapies may provide good results. However, in these type of combined treatments, the type of mesotherapy should be chosen and administered by specialist physicians.

PRP and mesotherapy can be applied in different sessions. The reason is, PRP has been proven to show its result immediately after the first injection and releases Growth Factor for up to 15 days. We can think that the cells will divide as PRP releases growth factor during this long period of time. In this respect, there is no harm in performing mesotherapy and PRP in separate sessions. Depending on the patient's condition, injections can be performed with PRP at the same time or in different sessions.