{"id":11089,"date":"2024-01-08T16:02:47","date_gmt":"2024-01-08T13:02:47","guid":{"rendered":"https:\/\/tlab.com.tr\/platelet-rich-plasma-administration-to-the-lower-anterior-vaginal-wall-to-improve-female-sexuality-satisfaction-copy-copy-copy-copy-copy\/"},"modified":"2025-03-26T11:58:24","modified_gmt":"2025-03-26T08:58:24","slug":"lipofilling-enriched-with-adipose-derived-mesenchymal-stem-cells-improves-soft-tissue-deformities-and-reduces-scar-pigmentation","status":"publish","type":"post","link":"https:\/\/tlab.com.tr\/en\/lipofilling-enriched-with-adipose-derived-mesenchymal-stem-cells-improves-soft-tissue-deformities-and-reduces-scar-pigmentation\/","title":{"rendered":"Lipofilling Enriched with Adipose-Derived Mesenchymal Stem Cells Improves Soft Tissue Deformities and Reduces Scar Pigmentation: Clinical and Instrumental Evaluation in Plastic Surgery"},"content":{"rendered":"<p><strong>Abstract<\/strong><\/p>\n<p><strong>Background<\/strong><\/p>\n<p>Scars and soft tissue deformities (S-STDs), often resulting from hemifacial atrophy, trauma, and outcomes of burns, were usually associated with hyperpigmentation of overlying skin.<\/p>\n<p><strong>Objectives<\/strong><\/p>\n<p>This study aimed to evaluate the long-term effects of fat grafting commonly called \u201cLipofilling\u201d enhanced with adipose-derived mesenchymal stem cells (Lipofilling-AD-MSCs) for treating S-STDs with pigmentary changes.<\/p>\n<p><strong>Methods<\/strong><\/p>\n<p>A cohort study has been performed. 50 patients affected by S-STDs with hyperpigmentation treated with Lipofilling-AD-MSCs and 50 patients treated with Lipofilling not enhanced (Lipofilling-NE) were prospectively assessed. The pre-op evaluation included a clinical evaluation, a photographic assessment, magnetic resonance imaging, and ultrasound. Post-op follow-up was performed at 1, 3, 7, 12, 24, 48, weeks, and then annually.<\/p>\n<p><strong>Results<\/strong><\/p>\n<p>Improvement in volume contours and pigmentation was clinically assessed. All people who underwent the treatments (Lipofilling-AD-MSCs and Lipofilling-NE) were satisfied with the improving pigmentation, texture, and volume contours with some differences. However, the results reported displaying a better trend in patients treated with Lipofilling-AD-MSCs to be more satisfied than patients treated with Lipofilling-NE (<em>p<\/em>\u00a0&lt; 0.0001).<\/p>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-16018d1d wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-text-align-center wp-element-button\" href=\"https:\/\/link.springer.com\/article\/10.1007\/s00266-023-03325-y\" target=\"_blank\" rel=\"noreferrer noopener\">Click here to read<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Abstract Background Scars and soft tissue deformities (S-STDs), often resulting from hemifacial atrophy, trauma, and outcomes of burns, were usually associated with hyperpigmentation of overlying skin. Objectives This study aimed to evaluate the long-term effects of fat grafting commonly called \u201cLipofilling\u201d enhanced with adipose-derived mesenchymal stem cells (Lipofilling-AD-MSCs) for treating S-STDs with pigmentary changes. Methods A cohort study has been performed. 50 patients affected by S-STDs with hyperpigmentation treated with Lipofilling-AD-MSCs and 50 patients treated with Lipofilling not enhanced (Lipofilling-NE) were prospectively assessed. The pre-op evaluation included a clinical evaluation, a photographic assessment, magnetic resonance imaging, and ultrasound. Post-op follow-up was performed at 1, 3, 7, 12, 24, 48, weeks, and then annually. Results Improvement in volume contours and pigmentation was clinically assessed. All people who underwent the treatments (Lipofilling-AD-MSCs and Lipofilling-NE) were satisfied with the improving pigmentation, texture, and volume contours with some differences. However, the results reported displaying a better trend in patients treated with Lipofilling-AD-MSCs to be more satisfied than patients treated with Lipofilling-NE (p\u00a0&lt; 0.0001).<\/p>","protected":false},"author":1,"featured_media":11092,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[58,108,83,98,62],"tags":[],"class_list":["post-11089","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-akademik-makaleler","category-dermatology_","category-dermatology","category-plastic-reconstructive-and-aesthetic-surgery","category-svf"],"views":166,"_links":{"self":[{"href":"https:\/\/tlab.com.tr\/en\/wp-json\/wp\/v2\/posts\/11089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tlab.com.tr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tlab.com.tr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tlab.com.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tlab.com.tr\/en\/wp-json\/wp\/v2\/comments?post=11089"}],"version-history":[{"count":3,"href":"https:\/\/tlab.com.tr\/en\/wp-json\/wp\/v2\/posts\/11089\/revisions"}],"predecessor-version":[{"id":12563,"href":"https:\/\/tlab.com.tr\/en\/wp-json\/wp\/v2\/posts\/11089\/revisions\/12563"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tlab.com.tr\/en\/wp-json\/wp\/v2\/media\/11092"}],"wp:attachment":[{"href":"https:\/\/tlab.com.tr\/en\/wp-json\/wp\/v2\/media?parent=11089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tlab.com.tr\/en\/wp-json\/wp\/v2\/categories?post=11089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tlab.com.tr\/en\/wp-json\/wp\/v2\/tags?post=11089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}